Company
Syntiron is an emerging biotechnology company located in Saint Paul, Minnesota, that is developing unique vaccines for human bacterial diseases. The company seeks to leverage its proprietary platform technology to develop bacterial vaccines for unmet human medical needs, including hospital infections, biodefense and diseases of the developing world. Syntiron is seeking a Protein Biochemist to accept a lead role in the preclinical development of its vaccine products.
Qualifications
Required:
M.S. in biochemistry or related field with 6+ years’ experience, or a Ph.D. with 3+ years of experience. Industrial experience is an important plus.
Experience with anion/cation exchange, size exclusion, and other affinity-based recombinant protein purification techniques.
Familiarity with 2D gel electrophoresis and 2D western blots.
Familiarity with quantitative protein techniques involving ESI mass spectrometry, such as ITRAQ.
Familiarity with bacterial membrane proteins.
Strong written and oral communication skills and an ability to provide scientific leadership.
Ability to work in a team environment, rapidly develop new techniques, and solve complex scientific problems in a highly independent manner.
Ability to grow and expand with the organization.
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Desired:
Experience working with insoluble integral membrane proteins (ie. purification, refolding, functional assays, etc.).
Experience with 2D gel separation of membrane proteins using cationic detergents (16-BAC).
Experience with quantitative protein techniques involving mass spectrometry.
Responsibilities:
The individual will initially spend approximately 75% time in the laboratory and be responsible for characterizing complex compositions of bacterial vaccine antigens using standard biochemical and proteomic techniques; developing experimental designs for the reconstitution of recombinant proteins into liposomes; characterizing, managing and expanding a library of recombinant candidate vaccine antigens; developing new experimental methodology; contributing to technical reports; managing junior scientific staff; and collaborating with other scientists on multiple projects.
If interested, please send a cover letter and resume to HR@syntiron.com. Competitive candidates will address in the cover letter how their scientific experiences qualify them to work with insoluble bacterial membrane proteins in the field of vaccine research.
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